Thrombotic Microangiopathic Glomerulopathy in Human Decay Accelerating Factor–Transgenic Swine-to-Baboon Kidney Xenografts

Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts.

Models of pig-to-baboon xenografting were examined to identify the mechanisms and pathologic characteristics of acute humoral xenograft rejection (AHXR). Thymus and kidney (composite thymokidney) from human decay accelerating factor-transgenic swine were transplanted into baboons (n = 16) that were treated with an immunosuppressive regimen that included extracorporeal immunoadsorption of anti-a...

Thrombotic microangiopathic haemolytic anaemia.

The syndrome of thrombotic microangiopathic haemolytic anaemia is rare and almost all the cases reported have been in adults. Very few cases occurring in childhood have been reported and the youngest recorded case was 22 months old (Craig and Gitlin, 1957). We report the clinical and pathological details and the response to treatment of a child aged 21 months, who was seen at the Austin Hospita...

Thrombotic microangiopathic haemolytic anaemia and antiphospholipid antibodies.

OBJECTIVE To analyse the clinical and laboratory features of patients with thrombotic microangiopathic haemolytic anaemia (TMHA) associated with antiphospholipid antibodies (aPL). METHODS A computer assisted (PubMed) search of the literature was performed to identify all cases of TMHA associated with aPL from 1983 to December 2002. RESULTS 46 patients (36 female) with a mean (SD) age at pre...

Thrombotic microangiopathic antiphospholipid syndromes: a continuum of conditions?

Thrombotic Microangiopathic Hemolytic Anemia without Evidence of Hemolytic Uremic Syndrome

Because of Yeneral’s extensive review [2] on atypical hemolytic uremic syndrome (aHUS) published recently in the Turkish Journal of Hematology, I brought it to readers’ attention that more recently some authors do not use ‘aHUS’, which was historically used to distinguish heterogeneous uncharacterized syndromes from Shiga toxin-related HUS, since the term lacks both specificity and suggested ca...